F667 Betamethasone - AK Scientific
 
 
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  Catalog ID # F667
Betamethasone
, 99% (HPLC)
 
Betadexamethasone
Flubenisolone
Rinderon
9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-16beta-methylprednisolone




IDENTITY
CAS Registry #:[378-44-9]
MDL Number:MFCD00062969
MF:C22H29FO5
MW:392.46
EINECS:206-825-4
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Available Spectra:NMR, LCMS, FT-IR, HPLC, Polarimetry
Physical Form:White to off-white powder
Melting Point:255-258°C
Optical Rotation:+115° - +121° (c=1, Dioxane)
Long-Term Storage:Store at room temperature
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Solubility:Water: 0.0063g/L (37°C)

REVIEW

 Betamethasone is glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. Betamethasone is a glucocorticoid receptor agonist.

REFERENCES
[1]Saraceno R, Gramiccia T, Frascione P, Chimenti S. Calcipotriene/betamethasone in the treatment of psoriasis: a review article. Expert Opin Pharmacother. (2009) Oct;10(14): 2357-65.
[2] Giardino G, Fusco A, Romano R, Gallo V, Maio F, Esposito T, Palamaro L, Parenti G, Salerno MC, Vajro P, Pignata C. Betamethasone therapy in ataxia telangiectasia: unraveling the rationale of this serendipitous observation on the basis of the pathogenesis. Eur J Neurol. (2013) May;20(5): 740-7.
[3] Basaran A, Basaran M, Sen C. Choice of glucocorticoid in HELLP syndrome - dexamethasone versus betamethasone: revisiting the dilemma. J Matern Fetal Neonatal Med. (2012) Dec;25(12): 2597-600.
[4] Taub, D.; Hoffsommer, R. D.; Slates, H. L.; Kuo, C. H.; Wendler, N. L.16beta-Methyl cortical steroids Journal of the American Chemical Society (1960), 82, 4012-26.

Risk Description(s)
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.



Pricing

CURRENT AS OF: September 30, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 F667_SDS.pdf

CATEGORIES

 APIs and Bioactives > Steroid Hormones

USEFUL LINKS

  PubChem