E105 Balsalazide disodium salt dihydrate - AK Scientific
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  Catalog ID # E105
formerly cat #69105
Balsalazide disodium salt dihydrate
, 98% (HPLC)
5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic acid disodium salt hydrate

CAS Registry #:[150399-21-6]
MDL Number:MFCD01631117
Purity:98% (HPLC)
Available Spectra:FT-IR, LCMS, HPLC
Physical Form:Yellow to orange to brown powder or crystalline powder
Melting Point:350°C
Long-Term Storage:Store long-term at 2-8°C
Shipping:Not Regulated for Shipping.
Ships overnight with cold pack.


 The mechanism of action of 5-aminosalicylic acid is unknown, but appears exert its anti-inflammatory effects locally (in the GI tract) rather than systemically. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways (catalyzes the formation of prostaglandin precursors from arachidonic acid), and through the lipoxygenase pathways (catalyzes the formation of leukotrienes and hydroxyeicosatetraenoic acids from arachidonic acid and its metabolites), is increased in patients with chronic inflammatory bowel disease. Therefore, it is possible that 5-aminosalicylic acid diminishes inflammation by blocking production of arachidonic acid metabolites in the colon through both the inhibition of cyclooxygenase and lipoxygenase.

[1]Wiggins JB, Rajapakse R: Balsalazide: a novel 5-aminosalicylate prodrug for the treatment of active ulcerative colitis. Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1279-84.
[2] Ragunath K, Williams JG: Review article: balsalazide therapy in ulcerative colitis. Aliment Pharmacol Ther. 2001 Oct;15(10):1549-54.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.

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M003Balsalazide disodium
E105Balsalazide disodium salt dihydrate

CURRENT AS OF: February 12, 2016

1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.
1. Not Required: Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.




 APIs and Bioactives > GI Diseases