[51-21-8] 5-Fluorouracil AKSci C526
 
 
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  Catalog ID # C526
5-Fluorouracil
, 98% (HPLC)
 
2,4-Dihydroxy-5-fluoropyrimidine
5-FU
5-Fluoro-2,4(1H,3H)-pyrimidinedione




IDENTITY
CAS Number:[51-21-8]
MDL Number:MFCD00006018
MF:C4H3FN2O2
MW:130.08
EINECS:200-085-6
BRN:127172
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, FT-IR, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:278-291°C
Boiling Point:190-200°C (0.1mmHg)
Long-Term Storage:Store at room temperature
UN #:UN2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Solubility:DMSO: 26mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL; MeOH; 1M NH4OH
Application(s):Thymidylate synthase inhibitor; DNA Synthesis
Form:Free Base

REVIEW

 An antimetabolite that is used for treatment of cancer. Fluorouracil is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase.

REFERENCES
[1]Khan MA, Masood N, Husain N, Ahmad B, Aziz T, Naeem A (2012). A retrospective study of cardiotoxicities induced by 5-fluouracil (5-FU) and 5-FU based chemotherapy regimens in Pakistani adult cancer patients at Shaukat Khanum Memorial Cancer Hospital & Research Center. J Pak Med Assoc. 62(5):430-4. PMID 22755303.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301; H412

Precautionary Statements
P264; P270; P273; P301+P310; P321; P330; P405; P501


Current as of December 4, 2016


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CATEGORIES

 APIs and Bioactives > Chemotherapeutics
 Heterocyclic Building Blocks > Pyrimidines, Ketones, Fluorine
  Nucleobases > Pyrimidines

USEFUL LINKS

  PubChem