C526 5-Fluorouracil - AK Scientific
 
 
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  Catalog ID # C526
formerly cat #67526
5-Fluorouracil
, 98% (HPLC)
 
2,4-Dihydroxy-5-fluoropyrimidine
5-FU
5-Fluoro-2,4(1H,3H)-pyrimidinedione




IDENTITY
CAS Registry #:[51-21-8]
MDL Number:MFCD00006018
MF:C4H3FN2O2
MW:130.08
EINECS:200-085-6
BRN:127172
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:HPLC
Physical Form:White to off-white crystalline powder
Melting Point:278-291°C
Boiling Point:190-200°C (0.1mmHg)
Long-Term Storage:Store at room temperature
Shipping:Regulated for Shipping
UN #:2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Solubility:DMSO: 26mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL; MeOH; 1M NH4OH
Application(s):Thymidylate synthase inhibitor; DNA Synthesis
Form:Free Base

REVIEW

 An antimetabolite that is used for treatment of cancer. Fluorouracil is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase.

REFERENCES
[1]Khan MA, Masood N, Husain N, Ahmad B, Aziz T, Naeem A (2012). A retrospective study of cardiotoxicities induced by 5-fluouracil (5-FU) and 5-FU based chemotherapy regimens in Pakistani adult cancer patients at Shaukat Khanum Memorial Cancer Hospital & Research Center. J Pak Med Assoc. 62(5):430-4. PMID 22755303.

Risk Description(s)
R25:Toxic if swallowed.
R52:Harmful to aquatic organisms.

Safety Description(s)
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



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CURRENT AS OF: February 13, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.
1. Not Required: Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

SDS

 C526_SDS.pdf

CATEGORIES

 APIs and Bioactives > Chemotherapeutics
 Heterocyclic Building Blocks > Pyrimidines, Ketones, Fluorine
  Nucleobases > Pyrimidines

USEFUL LINKS

  PubChem