C526 5-Fluorouracil - AK Scientific
 
 
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  Catalog ID # C526
5-Fluorouracil
, 98% (HPLC)
 
2,4-Dihydroxy-5-fluoropyrimidine
5-FU
5-Fluoro-2,4(1H,3H)-pyrimidinedione




IDENTITY
CAS Registry #:[51-21-8]
MDL Number:MFCD00006018
MF:C4H3FN2O2
MW:130.08
EINECS:200-085-6
BRN:127172
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, FT-IR, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:278-291°C
Boiling Point:190-200°C (0.1mmHg)
Long-Term Storage:Store at room temperature
Shipping:Regulated for Shipping
UN #:UN2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Solubility:DMSO: 26mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL; MeOH; 1M NH4OH
Application(s):Thymidylate synthase inhibitor; DNA Synthesis
Form:Free Base

REVIEW

 An antimetabolite that is used for treatment of cancer. Fluorouracil is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase.

REFERENCES
[1]Khan MA, Masood N, Husain N, Ahmad B, Aziz T, Naeem A (2012). A retrospective study of cardiotoxicities induced by 5-fluouracil (5-FU) and 5-FU based chemotherapy regimens in Pakistani adult cancer patients at Shaukat Khanum Memorial Cancer Hospital & Research Center. J Pak Med Assoc. 62(5):430-4. PMID 22755303.

Risk Description(s)
R25:Toxic if swallowed.
R52:Harmful to aquatic organisms.

Safety Description(s)
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



Pricing

CURRENT AS OF: September 25, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 C526_SDS.pdf

CATEGORIES

 APIs and Bioactives > Chemotherapeutics
 Heterocyclic Building Blocks > Pyrimidines, Ketones, Fluorine
  Nucleobases > Pyrimidines

USEFUL LINKS

  PubChem