B678 Tamibarotene - AK Scientific
 
 
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  Catalog ID # B678
formerly cat #66678
Tamibarotene
, 98% (HPLC)
 
AM 80
Amibaro
Amnolake
Amnoleuk




IDENTITY
CAS Registry #:[94497-51-5]
MDL Number:MFCD00866188
MF:C22H25NO3
MW:351.44
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:190-195°C
Long-Term Storage:Store at room temperature
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Solubility:DMSO: >=10 mg/mL
Application(s):Agonist for retinoic acid receptor alpha/beta

REVIEW

 Tamibarotene is an orally-active, synthetic retinoid, developed to overcome all-trans retinoic acid resistance, with potential antineoplastic activity. It is a retinoic acid receptor (RAR) agonist with high specificity for RARalpha and RARbeta over RARgamma that induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute promyelocytic leukemia in vivo. Temporarily and spatially specific expression of RARs suggests their pivotal roles in the adult brain. It is considered to be a promising candidate drug for treatment of Alzheimer's disease because of its transcriptional controls of multiple target genes involved in etiology and pathology of Alzheimer's disease.

REFERENCES
[1]Shudo, Koichi Benzoic acid derivatives Eur. Pat. Appl. (1986), EP 170105 A2 19860205.
[2] Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Shudo, Koichi; Himi, Toshiyuki Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity Journal of Medicinal Chemistry (1988), 31(11), 2182-92.
[3] Hamada, Yoshinori; Yamada, Isamu; Uenaka, Masaaki; Sakata, Teruo Preparation of 4-[(5,6,7,8-tetrahydro-5,6,8,8-terramethyl-2-naphthalenyl)carbamoyl]benzoic acid derivatives PCT Int. Appl. (1991), WO 9114673 A1 19911003.
[4] Eyrolles L; Kagechika H; Kawachi E; Fukasawa H; Iijima T; Matsushima Y; Hashimoto Y; Shudo K Retinobenzoic acids. 6. Retinoid antagonists with a heterocyclic ring Journal of medicinal chemistry (1994), 37(10), 1508-17.




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CURRENT AS OF: February 13, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.
1. Not Required: Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

SDS

 B678_SDS.pdf

CATEGORIES

 APIs and Bioactives > Chemotherapeutics

USEFUL LINKS

  PubChem  @PubMed