B678 Tamibarotene - AK Scientific
 
 
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  Catalog ID # B678
Tamibarotene
, 98% (HPLC)
 
AM 80
Amibaro
Amnolake
Amnoleuk




IDENTITY
CAS Registry #:[94497-51-5]
MDL Number:MFCD00866188
MF:C22H25NO3
MW:351.44
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:190-195°C
Long-Term Storage:Store at room temperature
Shipping:Not Regulated for Shipping

BIOLOGICAL INFO
Solubility:DMSO: >=10 mg/mL
Application(s):Agonist for retinoic acid receptor alpha/beta

REVIEW

 Tamibarotene is an orally-active, synthetic retinoid, developed to overcome all-trans retinoic acid resistance, with potential antineoplastic activity. It is a retinoic acid receptor (RAR) agonist with high specificity for RARalpha and RARbeta over RARgamma that induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute promyelocytic leukemia in vivo. Temporarily and spatially specific expression of RARs suggests their pivotal roles in the adult brain. It is considered to be a promising candidate drug for treatment of Alzheimer's disease because of its transcriptional controls of multiple target genes involved in etiology and pathology of Alzheimer's disease.

REFERENCES
[1]Shudo, Koichi Benzoic acid derivatives Eur. Pat. Appl. (1986), EP 170105 A2 19860205.
[2] Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Shudo, Koichi; Himi, Toshiyuki Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity Journal of Medicinal Chemistry (1988), 31(11), 2182-92.
[3] Hamada, Yoshinori; Yamada, Isamu; Uenaka, Masaaki; Sakata, Teruo Preparation of 4-[(5,6,7,8-tetrahydro-5,6,8,8-terramethyl-2-naphthalenyl)carbamoyl]benzoic acid derivatives PCT Int. Appl. (1991), WO 9114673 A1 19911003.
[4] Eyrolles L; Kagechika H; Kawachi E; Fukasawa H; Iijima T; Matsushima Y; Hashimoto Y; Shudo K Retinobenzoic acids. 6. Retinoid antagonists with a heterocyclic ring Journal of medicinal chemistry (1994), 37(10), 1508-17.




Pricing

CURRENT AS OF: September 30, 2016

Availability
1. Backordered: Please contact us for availability.
2. All prices FOB San Francisco, USA

HazMat
HazMat shipping information is based on IATA/DOT regulations. All of the information is for reference only and subject to change without notice.

Quality
1. All products' quality is guaranteed.
2. Lot-specific spectra and CoA available on request.

Usage
AK Scientific products are intended for Research and Development usage only. The products are not to be used for other purposes, including, but not limited to, human or animal use, or as a component in, a food, drug, medical device (including in vitro diagnostic reagents), cosmetics and pesticides.

The hazards associated with this chemical have not been fully evaluated. This chemical is to be used for research and development purposes only, under the supervision of a technically qualified individual.

AK Scientific is not an EPA registered pesticidal establishment. Our products are not intended for pesticidal applications.

SDS

 B678_SDS.pdf

CATEGORIES

 APIs and Bioactives > Chemotherapeutics

USEFUL LINKS

  PubChem  @PubMed