69778 Triclosan - AK Scientific
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  Catalog ID # 69778
, 98% (HPLC)

CAS Registry #:[3380-34-5]
MDL Number:MFCD00800992
Purity:98% (HPLC)
Physical Form:White to off-white crystalline powder or flakes
Melting Point:54-59°C
Boiling Point:280-290°C
Shipping:Regulated for Shipping.
UN #:3077
Hazard Class:9
Packing Group:III

Solubility:H2O: insoluble; DMSO: 15mg/mL; MeOH: 25mg/mL


 At in-use concentrations, triclosan acts as a biocide, with multiple cytoplasmic and membrane targets. At lower concentrations, however, triclosan appears bacteriostatic and is seen to target bacteria mainly by inhibiting fatty acid synthesis. Triclosan binds to bacterial enoyl-acyl carrier protein reductase enzyme (ENR), which is encoded by the gene FabI. This binding increases the enzyme's affinity for nicotinamide adenine dinucleotide (NAD+). This results in the formation of a stable ternary complex of ENR-NAD+-triclosan, which is unable to participate in fatty acid synthesis. Fatty acids are necessary for reproducing and building cell membranes. Humans do not have an ENR enzyme, and thus are not affected. Some bacterial species can develop low-level resistance to triclosan at its lower bacteriostatic concentrations because of FabI mutations, which results in a decrease of triclosan's effect on ENR-NAD+ binding, as shown in Escherichia coli and Staphylococcus aureus. Another way for these bacteria to gain low-level resistance to triclosan is to overexpress FabI. Some bacteria have innate resistance to triclosan at low, bacteriostatic levels, such as Pseudomonas aeruginosa, which possesses multi-drug efflux pumps that ''pump'' triclosan out of the cell.[18] Other bacteria, such as some of the Bacillus genus, have alternative FabI genes (FabK) to which triclosan does not bind and hence are less susceptible.

[1]Russell AD (2004). ''Whither triclosan?''. J. Antimicrob. Chemother. 53 (5): 693-5. doi:10.1093/jac/dkh171. PMID 15073159.
[2] Heath RJ, Rubin JR, Holland DR, Zhang E, Snow ME, Rock CO (1999). ''Mechanism of triclosan inhibition of bacterial fatty acid synthesis''. J. Biol. Chem. 274 (16): 11110-4. doi:10.1074/jbc.274.16.11110. PMID 10196195.
[3] Fan F, Yan K, Wallis NG, et al. (2002). ''Defining and combating the mechanisms of triclosan resistance in clinical isolates of Staphylococcus aureus''. Antimicrob. Agents Chemother. 46 (11): 3343-7. doi:10.1128/AAC.46.11.3343-3347.2002. PMC 128739. PMID 12384334.
[4] Slater-Radosti C, Van Aller G, Greenwood R, et al. (2001). ''Biochemical and genetic characterization of the action of triclosan on Staphylococcus aureus''. J. Antimicrob. Chemother. 48 (1): 1-6. doi:10.1093/jac/48.1.1. PMID 11418506.

Risk Description(s)
R36/38:Irritating to eyes and skin
R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment

Safety Description(s)
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39:Wear eye/face protection.
S46:If swallowed, seek medical advice immediately and show this container or label.
S60:This material and its container must be disposed of as hazardous waste.
S61:Avoid release to the environment. Refer to special instructions/Safety data sheets.

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CURRENT AS OF: March 29, 2015
1. In Stock: Order today by 4 PM PT and ships today from San Francisco, CA, USA
2. Backordered: Please contact us for availability.
3. If Bulk (kg) is Backordered, sizes less than 1kg may be available.
4. All prices FOB San Francisco, CA, USA
HazMat shipping information is based on IATA/DOT regulations. For reference only.
1. Not Required: Not regulated by IATA/DOT. Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.




 APIs and Bioactives > Antibacterials, Fungicides