67526 5-Fluorouracil - AK Scientific
 
 
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  Catalog ID # 67526
5-Fluorouracil
, 98% (HPLC)
 
2,4-Dihydroxy-5-fluoropyrimidine
5-FU
5-Fluoro-2,4(1H,3H)-pyrimidinedione




IDENTITY
CAS Registry #:[51-21-8]
MDL Number:MFCD00006018
MF:C4H3FN2O2
MW:130.08
EINECS:200-085-6
BRN:127172
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:HPLC
Physical Form:White to off-white crystalline powder
Melting Point:278-291°C
Boiling Point:190-200°C (0.1mmHg)
Shipping:Regulated for Shipping.
UN #:2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Solubility:DMSO: 26mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL; MeOH; 1M NH4OH
Application(s):Thymidylate synthase inhibitor; DNA Synthesis
Form:Free Base

REVIEW

 An antimetabolite that is used for treatment of cancer. Fluorouracil is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase.

REFERENCES
[1]Khan MA, Masood N, Husain N, Ahmad B, Aziz T, Naeem A (2012). A retrospective study of cardiotoxicities induced by 5-fluouracil (5-FU) and 5-FU based chemotherapy regimens in Pakistani adult cancer patients at Shaukat Khanum Memorial Cancer Hospital & Research Center. J Pak Med Assoc. 62(5):430-4. PMID 22755303.

Risk Description(s)
R25:Toxic if swallowed.
R52:Harmful to aquatic organisms.

Safety Description(s)
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



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CURRENT AS OF: March 29, 2015
Availability
1. In Stock: Order today by 4 PM PT and ships today from San Francisco, CA, USA
2. Backordered: Please contact us for availability.
3. If Bulk (kg) is Backordered, sizes less than 1kg may be available.
4. All prices FOB San Francisco, CA, USA
HazMat
HazMat shipping information is based on IATA/DOT regulations. For reference only.
1. Not Required: Not regulated by IATA/DOT. Normal shipping for Ground and Express.
2. Required for Express: HazMat shipping via Express. Normal shipping for continental Ground.

SDS

 67526_SDS.pdf

CATEGORIES

 Heterocyclic Building Blocks > Pyrimidines, Ketones, Fluorine
 APIs and Bioactives > Chemotherapeutics
  Nucleobases > Pyrimidines

USEFUL LINKS

  PubChem