491878-06-9 4-Nitrobenzyl (2S,4S)-4-acetylthio-2-[[N-sulfamoyl-N-(tert-butoxycarbonyl)amino]methyl]pyrrolidine-1-carboxylate AKSci B709
 
 
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  B709    AKSci Bulk Reagent
4-Nitrobenzyl (2S,4S)-4-acetylthio-2-[[N-sulfamoyl-N-(tert-butoxycarbonyl)amino]methyl]pyrrolidine-1-carboxylate, >98% (HPLC)
 
Doripenem side-chain
IDENTITY
CAS Number:491878-06-9
MDL Number:MFCD14635210
MF:C20H28N4O9S2
MW:532.59
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:137-139°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 An advanced intermediate used in the preparation carbopenems such as doripenem.

REFERENCES
[1]Nishino, Yutaka; Yuasa, Tetsuya; Komurasaki, Tadashi; Kakinuma, Makoto; Masui, Toshiaki; Kobayashi, Makoto Preparation of sulfamides and pyrrolidines as intermediates for pyrrolidylthiocarbapenem antibiotic Jpn. Kokai Tokkyo oho (2003), JP 2003026680 A 20030129.
[2] Nishino, Yutaka; Kobayashi, Makoto; Shinno, Taneyoshi; Izumi, Kenji; Yonezawa, Hiroshi; Masui, Yoshiyuki; Takahira, Masayuki Practical Large-Scale Synthesis of Doripenem: A Novel 1beta-Methylcarbapenem Antibiotic Organic Process Research & Development (2003), 7(6), 846-850.
[3] Uenaka, Masaaki; Ide, Yutaka; Nagai, Masahiko; Yabunaka, Hiromi Preparation of 2-[1-[(allyloxycarbonyl)methyl]-3-(1-hydroxyethyl)-4-oxoazetidin-2-yl]propanoic acid as intermediate for synthesizing carbapenem and method for preparation thereof PCT Int. Appl. (2006), WO 2006049113 A1 20060511.
[4] Tewari, Neera; Meeran, Hashim Nizar Poovanathi Nagoor; Rai, Bishwa Prakash; George, A process for the preparation of doripenem PCT Int. Appl. (2006), WO 2006117763 A2 20061109.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
B7094-Nitrobenzyl (2S,4S)-4-acetylthio-2-[[N-sulfamoyl-N-(tert-butoxycarbonyl)amino]methyl]pyrrolidine-1-carboxylate
P236Doripenem hydrate
P521Doripenem

Current as of April 19, 2024


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CATEGORIES
 APIs and Bioactives > Carbapenems
 Chiral Synthesis > Pyrrolidines
 Chiral Synthesis > Pyrrolidines


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